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Premium Stilbene Glucoside 98% (He Shou Wu Extract) -2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside CAS 82373-94-2
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside 98% is a high-purity bioactive compound derived from Polygonum multiflorum (He Shou Wu), certified by ISO 9001. This ingredient delivers triple-action efficacy for nutraceutical and cosmetic formulations:
Anti-Aging Power
Metabolic Health Support
Neuroprotection
Product Name :
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucosideCAS No. :
82373-94-2Appearance :
Off-white to pale yellow crystalline powderSpecification :
98%🌿 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside 98% (CAS: 82373-94-2)
Source: Polygonum multiflorum (He Shou Wu) Root Extract
Molecular Formula: C₂₀H₂₂O₉
Molecular Weight: 406.38 g/mol
Appearance: Off-white to pale yellow crystalline powder (hygroscopic)
≥98% Purity (HPLC-validated, λmax 320 nm)
Antioxidant Defense:
Scavenges ROS with IC₅₀ of 11.4 μM, outperforming standard antioxidants
Inhibits lipid peroxidation by 78% in liver tissue models
Anti-Aging & Skin Revitalization:
Stimulates collagen synthesis via TGF-β activation
Metabolic Health Support:
Lowers serum TC and LDL-C by 52% in hyperlipidemic models
Protects hepatocytes from oxidative damage
Skin Rejuvenation
Wrinkle Reduction: 0.5% cream decreases wrinkle depth by 34% in UV-exposed skin after 12 weeks
Elasticity Improvement: ↑ skin firmness by 29% (cutometer assessment)
Cognitive & Vascular Health
Neuroprotection: Enhances learning memory in brain-injury models by 41%
Atherosclerosis Prevention: Suppresses foam cell formation by 63% via LDL-R upregulation
Liver Protection
Fatty Liver Management: Reduces hepatic triglycerides by 48% at 50 mg/kg dosage
Detoxification Support: Upregulates glutathione-S-transferase (GST)
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-PDA, ISO 9001 compliant) |
| Solubility | Methanol (50 mg/mL), Ethanol (40 mg/mL), Water (limited; use solubilized grades) |
| Melting Point | 184–186°C |
| Storage | 2–8°C in amber glass (24-month stability) |
| Key Impurities | Emodin ≤0.2%, Physcion ≤0.1% |
| Heavy Metals | Pb ≤0.5 ppm, As ≤0.1 ppm |
Nutraceuticals: Liver-detox capsules (50–100 mg/day), cognitive support tablets.
Cosmeceuticals: Anti-aging serums, brightening creams (synergizes with niacinamide).
Pharmaceuticals: Adjuvant for cardiovascular and neuroprotective formulations.
Green Extraction
Ultrasonic-assisted ethanol/water extraction → D101 resin purification (yield 92%, solvent-free)
Enhanced Bioavailability
Phospholipid complexation increases dermal penetration 4.5× vs. free form
Stability Optimization
Nano-encapsulation with tocopherol acetate (96% retention after 3 months at 40°C)
| Quantity | Format | Shelf Life | |
|---|---|---|---|
| 100 g | Amber glass vial + argon | 24 months | |
| 1 kg | Vacuum-sealed aluminum pouch | 24 months | |
| 25 kg | Pharma HDPE drum (2–8°C, RH<30%) | 24 months |
Non-Toxic: LD₅₀ >2,000 mg/kg
Non-Irritating: HET-CAM score 0.2
Certifications: ISO 9001
Q: How to improve water solubility for serums?
*A: Use solubilized grade (pre-encapsulated) or blend with glycerin (1:3 ratio) → add to aqueous phase at 60°C.
Q: Stability in acidic formulations (pH 3.0)?
A: Limited stability below pH 4.0; optimal range pH 5.0–7.0 (>90% retention).
Q: Synergistic partners for hyperpigmentation?
A: Combine with tranexamic acid (↓58% melanin) or licorice extract (↑2.1× tyrosinase inhibition).
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