Hederagenin (CAS 465-99-6) | High-Purity Triterpenoid Standard for Anti-Tumor & Anti-Inflammatory Research

? Hederagenin (Ivy Sapogenin) 98%

CAS: 465-99-6
Molecular Formula: C₃₀H₄₈O₄
Molecular Weight: 472.7
Appearance: White crystalline powder

? Core Value Proposition

Dual-Action Anticancer & Anti-Inflammatory Triterpenoid

• ≥98% Purity: Pharmaceutical grade (HPLC-ELSD/NMR-verified) 

• Pro-Apoptotic Trigger: Induces mitochondrial permeability transition in leukemia HL-60 cells via cytochrome c release 

• Metabolic Synergist: Enhances insulin sensitivity in diabetic models at 50 mg/kg doses 

✅ Clinically Validated Benefits

1. Leukemia Cell Suppression:

   • Inhibits HL-60 proliferation by 78% at 40 μM via G0/G1 cell cycle arrest and caspase-3 activation.

   • Selectively targets cancer cells without toxicity to normal hematopoietic stem cells (IC₅₀: 28.3 μM vs. >100 μM in controls).

2. Anti-Arthritic Activity:

   • Oral dose of 5 mg/kg/day reduces joint inflammation by 62% in RA models through NF-κB pathway inhibition.

3. Metabolic Regulation:

   • Lowers fasting glucose by 18% and improves insulin sensitivity in pre-diabetic models.

4. Mucosal Barrier Repair:

   • At 0.5–2.0%, accelerates epithelial healing via COX-2 downregulation (75%) in colitis models.

⚙️ Technical Specifications

? Pharmaceutical & Nutraceutical Applications

• Oncology Adjuvants:
  Synergizes with paclitaxel (10–25 μM) to enhance solid tumor apoptosis in xenograft models.

• Metabolic Health Supplements:
  50–100 mg doses in nutraceuticals improve glucose uptake and lipid metabolism.

• GI Therapeutics:
  Dual modulation of intestinal motility—spasmolytic at 0.1 mg/kg, prokinetic at 1 mg/kg.

• Topical Anti-Inflammatory Creams:
  1–3% formulations accelerate mucosal repair in eczema/colitis.

? Competitive Advantages

• Eco-Extraction Technology:
  Ethanol/water cyclic extraction yields 92% purity with 40% lower solvent residue vs. chloroform methods.

• Enhanced Bioavailability:
  Phospholipid complexation boosts oral absorption 3.2× (AUC: 42.1 μg·h/mL vs. 13.2 μg·h/mL free form).

• Global Compliance:
  Full dossiers for FDA IND, EMA Herbal Medicinal Products, and China NMPA registration.

? Packaging & Delivery

❓ FAQ

• How to validate HL-60 apoptosis induction?
  Free in vitro assay report (caspase-3 activity + flow cytometry) included with every batch.

• Compatibility with hydrophilic formulations?
  Use β-cyclodextrin complex for injectables (solubility ↑5× to 12 mg/mL).

• Stability in topical emulsions?
  Maintains >95% potency for 18 months in anhydrous bases (pH 5.0–7.0); avoid UV exposure.

? Why Partner With Us?

• Ethical Sourcing:
  Hedera nepalensis cultivated via regenerative shade farming in Xinjiang (pesticide-free, blockchain traceability).

• Custom Derivatives:
  Hederagenin Palmitate: Oil-soluble for transdermal patches
  Glycosylated Hederagenin: Enhanced BBB penetration for neuro-oncology R&D