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Croceic Acid (Crocetin) CAS 27876 - 94 - 4: A Multifunctional Carotenoid for Cosmeceutical Health
Croceic Acid (Crocetin), with CAS No. 27876 - 94 - 4 and a molecular formula of C₂₀H₂₄O₄, is a remarkable multifunctional carotenoid sourced from Crocus sativus L. (saffron stigma) and Gardenia jasminoides fruits. It presents as brick - red orthorhombic crystals and has a molecular weight of 328.40 g/mol.
Product Name :
CrocetinCAS No. :
27876-94-4Appearance :
Brick-red orthorhombic crystalsSpecification :
98%CAS No.: 27876-94-4
Molecular Formula: C₂₀H₂₄O₄
Molecular Weight: 328.40 g/mol
Appearance: Brick-red orthorhombic crystals
Source: Crocus sativus L. (saffron stigma), Gardenia jasminoides fruits
Multifunctional Carotenoid for Metabolic & Cellular Health
≥99% Purity (HPLC-validated): Batch-to-batch consistency ensured.
Bile Metabolism Regulator: Reduces bilirubin by 52% in bile duct-ligated rabbits (dose-dependent).
Antiatherogenic Activity: 63% decrease in aortic plaques in cholesterol-fed rabbit models.
Hepatoprotection & Metabolic Health
NAFLD/Fatty Liver Support: 100 mg/kg/day reduces liver triglycerides by 48% via AMPK activation.
Cholesterol Management: Inhibits arterial plaque formation in hypercholesterolemic models.
Oncological Applications
Antitumor Activity: Synergizes with chemotherapy agents (e.g., doxorubicin), inducing apoptosis via Bax/Bcl-2 pathway.
Cosmeceutical Benefits
UV Protection: Topical 1-3% formulations inhibit MMP-1 (82%) and prevent collagen degradation.
| Parameter | Specification |
|---|---|
| Purity | ≥99% (HPLC-DAD, λmax 238 nm) |
| Melting Point | 285–286°C |
| Solubility | Soluble in pyridine/alkaline solutions; insoluble in water, ethanol, methanol |
| Storage | 2–8°C in airtight, light-resistant containers (24-month stability) |
| Key Impurities | Residual solvents ≤0.5% (GC-MS monitored) |
| Density | 1.085±0.06 g/cm³ (20°C) |
1. Nutraceuticals & Pharmaceuticals
Liver Health Formulations: 50–100 mg capsules for NAFLD/cholesterol management.
Oncology Adjuvants: Enhances chemo efficacy while reducing toxicity (10–25 mg/kg doses).
2. Functional Foods
Natural Colorant: Approved for beverages/baked goods (pH-stable in alkaline emulsions).
3. Cosmeceuticals
Anti-Aging Serums: 1–3% concentrations in PEG-400 bases for topical delivery.
1. Green Extraction Technology
Solvent-free, yield ≥96%, energy-efficient vs. solvent methods.
2. Global Compliance Ready
Heavy metals controlled (As <0.1 ppm, Pb <0.2 ppm; ICP-MS).
3. Polymorph Stability
Orthorhombic crystals maintain integrity at ≤140°C (ideal for tablet compression).
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 5 mg–100 mg | Amber glass vial + desiccant | 24 months |
| 1 g–5 kg | Pharma-grade HDPE drum + vacuum seal | 24 months |
| 10–25 kg | UN-certified fiber drum (palletized) | 24 months |
Acute Toxicity: LD₅₀ (oral, rat) >5,000 mg/kg; non-genotoxic.
Allergen-Free: Certified gluten/dairy/nut-free.
Q1: How to verify antitumor activity in batches?
→ Batch-specific apoptosis assay reports (HL-60/SMMC-7721 cells) included.
Q2: Solubility for injectable formulations?
→ Use pyridine-based carriers (solubility ↑ to 50 mg/mL).
Q3: Stability in high-pH functional foods?
→ Stable at pH 8–10 with 0.1% ascorbyl palmitate antioxidant.
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