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Croceic Acid (Crocetin) CAS 27876 - 94 - 4: A Multifunctional Carotenoid for Cosmeceutical Health

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Croceic Acid (Crocetin) CAS 27876 - 94 - 4: A Multifunctional Carotenoid for Cosmeceutical Health

Croceic Acid (Crocetin) CAS 27876 - 94 - 4: A Multifunctional Carotenoid for Cosmeceutical Health

Croceic Acid (Crocetin), with CAS No. 27876 - 94 - 4 and a molecular formula of C₂₀H₂₄O₄, is a remarkable multifunctional carotenoid sourced from Crocus sativus L. (saffron stigma) and Gardenia jasminoides fruits. It presents as brick - red orthorhombic crystals and has a molecular weight of 328.40 g/mol.

  • Product Name :

    Crocetin
  • CAS No. :

    27876-94-4
  • Appearance :

    Brick-red orthorhombic crystals
  • Specification :

    98%

🌿 Croceic Acid (Crocetin)

CAS No.: 27876-94-4
Molecular Formula: C₂₀H₂₄O₄
Molecular Weight: 328.40 g/mol
Appearance: Brick-red orthorhombic crystals
Source: Crocus sativus L. (saffron stigma), Gardenia jasminoides fruits


⚡️ Core Value Proposition

Multifunctional Carotenoid for Metabolic & Cellular Health

  • ≥99% Purity (HPLC-validated): Batch-to-batch consistency ensured.

  • Bile Metabolism Regulator: Reduces bilirubin by 52% in bile duct-ligated rabbits (dose-dependent).

  • Antiatherogenic Activity: 63% decrease in aortic plaques in cholesterol-fed rabbit models.


✅ Biologically Validated Functions

  1. Hepatoprotection & Metabolic Health

    • NAFLD/Fatty Liver Support: 100 mg/kg/day reduces liver triglycerides by 48% via AMPK activation.

    • Cholesterol Management: Inhibits arterial plaque formation in hypercholesterolemic models.

  2. Oncological Applications

    • Antitumor Activity: Synergizes with chemotherapy agents (e.g., doxorubicin), inducing apoptosis via Bax/Bcl-2 pathway.

  3. Cosmeceutical Benefits

    • UV Protection: Topical 1-3% formulations inhibit MMP-1 (82%) and prevent collagen degradation.


⚙️ Technical Specifications

Parameter Specification
Purity ≥99% (HPLC-DAD, λmax 238 nm)
Melting Point 285–286°C
Solubility Soluble in pyridine/alkaline solutions; insoluble in water, ethanol, methanol
Storage 2–8°C in airtight, light-resistant containers (24-month stability)
Key Impurities Residual solvents ≤0.5% (GC-MS monitored)
Density 1.085±0.06 g/cm³ (20°C)

🧪 Applications

1. Nutraceuticals & Pharmaceuticals

  • Liver Health Formulations: 50–100 mg capsules for NAFLD/cholesterol management.

  • Oncology Adjuvants: Enhances chemo efficacy while reducing toxicity (10–25 mg/kg doses).

2. Functional Foods

  • Natural Colorant: Approved for beverages/baked goods (pH-stable in alkaline emulsions).

3. Cosmeceuticals

  • Anti-Aging Serums: 1–3% concentrations in PEG-400 bases for topical delivery.


🚀 Competitive Advantages

1. Green Extraction Technology

  • Solvent-free, yield ≥96%, energy-efficient vs. solvent methods.

2. Global Compliance Ready

  • Heavy metals controlled (As <0.1 ppm, Pb <0.2 ppm; ICP-MS).

3. Polymorph Stability

  • Orthorhombic crystals maintain integrity at ≤140°C (ideal for tablet compression).


📦 Industrial Packaging

Quantity Packaging Method Shelf Life
5 mg–100 mg Amber glass vial + desiccant 24 months
1 g–5 kg Pharma-grade HDPE drum + vacuum seal 24 months
10–25 kg UN-certified fiber drum (palletized) 24 months

⚠️ Safety & Toxicology

  • Acute Toxicity: LD₅₀ (oral, rat) >5,000 mg/kg; non-genotoxic.

  • Allergen-Free: Certified gluten/dairy/nut-free.


❓ Critical FAQs

Q1: How to verify antitumor activity in batches?
→ Batch-specific apoptosis assay reports (HL-60/SMMC-7721 cells) included.

Q2: Solubility for injectable formulations?
→ Use pyridine-based carriers (solubility ↑ to 50 mg/mL).

Q3: Stability in high-pH functional foods?
→ Stable at pH 8–10 with 0.1% ascorbyl palmitate antioxidant.

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Croceic Acid (Crocetin) CAS 27876 - 94 - 4: A Multifunctional Carotenoid for Cosmeceutical Health

Croceic Acid (Crocetin), with CAS No. 27876 - 94 - 4 and a molecular formula of C₂₀H₂₄O₄, is a remarkable multifunctional carotenoid sourced from Crocus sativus L. (saffron stigma) and Gardenia jasminoides fruits. It presents as brick - red orthorhombic crystals and has a molecular weight of 328.40 g/mol.

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